MyBioSource.com's TNFRSF11B Antibody (Center) is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, Immunofluorescence, Immunohistochemistry, and Western Blot. The TNFRSF11B Antibody (Center) was generated using osteoprotegerin, and TNFRSF11B as the antigen and it reacts with Human.
Description
The protein encoded by this gene is a member of the
TNF-receptor superfamily. This protein is an osteoblast-secreted
decoy receptor that functions as a negative regulator of bone
resorption. This protein specifically binds to its ligand,
osteoprotegerin ligand, both of which are key extracellular
regulators of osteoclast development. Studies of the mouse
counterpart also suggest that this protein and its ligand play a
role in lymph-node organogenesis and vascular calcification.
Alternatively spliced transcript variants of this gene have been
reported, but their full length nature has not been determined